Biotin Anti-Human/Mouse CD45R (B220) (RA3-6B2)
The RA3-6B2 antibody reacts with the human and mouse CD45 isoform known as CD45R, or B220, a protein tyrosine phosphatase of ā„ 220 kDa. CD45 is one of the most abundant hematopoietic markers, and is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). Various isoforms are generated and expressed in cell-specific patterns, all critical for leukocyte function. In mouse, the CD45R/B220 isoform is predominantly found on B cells, at varying levels on all stages from pro-B cells to activated B cells, and may also be detected on certain T cell and NK cell subsets. It is of note that B220 is not similarly expressed on human B cells, where it appears to be differentiation-specific and therefore expressed on only some B cell subsets. Other forms of CD45 with restricted cellular expression include CD45RA, CD45RB, CD45RO and several others.
The RA3-6B2 antibody is one of the most consistently used leukocyte markers for B cells, T cell subsets and NK cell subsets in human and mouse. This antibody has also been reported as cross-reactive with feline CD45R/B220.
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Recent Publications:
Racine JJ, Chapman HD, Doty R, Cairns BM, Hines TJ, Tadenev ALD, Anderson LC, Green T, Dyer ME, Wotton JM, Bichler Z, White JK, Ettinger R, Burgess RW, Serreze DV. T Cells from NOD-PerIgĀ Mice Target Both Pancreatic and Neuronal Tissue. J Immunol. 2020 Sep 16:ji2000114. doi: 10.4049/jimmunol.2000114. PMID: 32938729.
| Name | Biotin Anti-Human/Mouse CD45R (B220) (RA3-6B2) |
|---|---|
| Cat. No. | 30-0452 |
| Alternative Names | Ly-5, Lyt-4, T200 |
| Gene ID | 19264 |
| Clone | RA3-6B2 |
| Isotype | Rat IgG2a, Īŗ |
| Reactivity | Human, Mouse |
| Cross Reactivity | Feline |
| Format | Biotin |
| Application | Flow Cytometry |
The RA3-6B2 antibody reacts with the human and mouse CD45 isoform known as CD45R, or B220, a protein tyrosine phosphatase of ā„ 220 kDa. CD45 is one of the most abundant hematopoietic markers, and is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). Various isoforms are generated and expressed in cell-specific patterns, all critical for leukocyte function. In mouse, the CD45R/B220 isoform is predominantly found on B cells, at varying levels on all stages from pro-B cells to activated B cells, and may also be detected on certain T cell and NK cell subsets. It is of note that B220 is not similarly expressed on human B cells, where it appears to be differentiation-specific and therefore expressed on only some B cell subsets. Other forms of CD45 with restricted cellular expression include CD45RA, CD45RB, CD45RO and several others.
The RA3-6B2 antibody is one of the most consistently used leukocyte markers for B cells, T cell subsets and NK cell subsets in human and mouse. This antibody has also been reported as cross-reactive with feline CD45R/B220.
Ā
Recent Publications:
Racine JJ, Chapman HD, Doty R, Cairns BM, Hines TJ, Tadenev ALD, Anderson LC, Green T, Dyer ME, Wotton JM, Bichler Z, White JK, Ettinger R, Burgess RW, Serreze DV. T Cells from NOD-PerIgĀ Mice Target Both Pancreatic and Neuronal Tissue. J Immunol. 2020 Sep 16:ji2000114. doi: 10.4049/jimmunol.2000114. PMID: 32938729.
| Name | Biotin Anti-Human/Mouse CD45R (B220) (RA3-6B2) |
|---|---|
| Cat. No. | 30-0452 |
| Alternative Names | Ly-5, Lyt-4, T200 |
| Gene ID | 19264 |
| Clone | RA3-6B2 |
| Isotype | Rat IgG2a, Īŗ |
| Reactivity | Human, Mouse |
| Cross Reactivity | Feline |
| Format | Biotin |
| Application | Flow Cytometry |
Original: $21.00
-70%$21.00
$6.30Description
The RA3-6B2 antibody reacts with the human and mouse CD45 isoform known as CD45R, or B220, a protein tyrosine phosphatase of ā„ 220 kDa. CD45 is one of the most abundant hematopoietic markers, and is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). Various isoforms are generated and expressed in cell-specific patterns, all critical for leukocyte function. In mouse, the CD45R/B220 isoform is predominantly found on B cells, at varying levels on all stages from pro-B cells to activated B cells, and may also be detected on certain T cell and NK cell subsets. It is of note that B220 is not similarly expressed on human B cells, where it appears to be differentiation-specific and therefore expressed on only some B cell subsets. Other forms of CD45 with restricted cellular expression include CD45RA, CD45RB, CD45RO and several others.
The RA3-6B2 antibody is one of the most consistently used leukocyte markers for B cells, T cell subsets and NK cell subsets in human and mouse. This antibody has also been reported as cross-reactive with feline CD45R/B220.
Ā
Recent Publications:
Racine JJ, Chapman HD, Doty R, Cairns BM, Hines TJ, Tadenev ALD, Anderson LC, Green T, Dyer ME, Wotton JM, Bichler Z, White JK, Ettinger R, Burgess RW, Serreze DV. T Cells from NOD-PerIgĀ Mice Target Both Pancreatic and Neuronal Tissue. J Immunol. 2020 Sep 16:ji2000114. doi: 10.4049/jimmunol.2000114. PMID: 32938729.
| Name | Biotin Anti-Human/Mouse CD45R (B220) (RA3-6B2) |
|---|---|
| Cat. No. | 30-0452 |
| Alternative Names | Ly-5, Lyt-4, T200 |
| Gene ID | 19264 |
| Clone | RA3-6B2 |
| Isotype | Rat IgG2a, Īŗ |
| Reactivity | Human, Mouse |
| Cross Reactivity | Feline |
| Format | Biotin |
| Application | Flow Cytometry |
