APC-Cyanine7 Anti-Mouse TCR beta (H57-597)
The H57-597 antibody is specific for the beta chain of the mouse T cell Receptor (TCR). This cell surface protein combines with a second protein chain (alpha chain) to form the alpha-beta TCR that is expressed by NK1.1+ thymocytes, NKT cells, and the majority of peripheral T cells. A small number of T cells may express an alternative heteromer of gamma/delta protein chains, known as the g/d TCR. These receptors participate in a complex with CD3, and with the co-receptors CD4 or CD8, to recognize and respond to antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death.
The H57-597 antibody is used as a phenotypic marker for T cells expressing the alpha-beta TCR. It is also widely used to cross-link surface TCR and thereby mimic TCR-mediated cell activation or induction of apoptosis. The antibody does not cross-react with cells expressing the g/d TCR.
Recent Publications:
Bescucci DM, Clarke ST, Brown CLJ, et al. The absence of murine cathelicidin-related antimicrobial peptide impacts host responses enhancing Salmonella enterica serovar Typhimurium infection. Gut Pathog. 2020 Nov 13;12(1):53. doi: 10.1186/s13099-020-00386-1. PMID: 33292444; PMCID: PMC7666523.
Karki R, Sharma BR, Lee E, et al. Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer.Ā JCI Insight. 2020;5(12):136720. Published 2020 Jun 18. doi:10.1172/jci.insight.136720.
Kondo M, Tanaka Y, Kuwabara T, Naito T, Kohwi-Shigematsu T and Watanabe A. 2015. J Immunol. doi: 10.4049/jimmunol.1501429. (Flow Cytometry)
| Name | APC-Cyanine7 Anti-Mouse TCR beta (H57-597) |
|---|---|
| Cat. No. | 25-5961 |
| Alternative Names | TCRb, TCRbeta, TCR-b chain, TCR-b, b-TCR |
| Gene ID | 21577 |
| Clone | H57-597 |
| Isotype | Armenian Hamster IgG |
| Reactivity | Mouse |
| Format | APC-Cyanine7 |
| Application | Flow Cytometry |
The H57-597 antibody is specific for the beta chain of the mouse T cell Receptor (TCR). This cell surface protein combines with a second protein chain (alpha chain) to form the alpha-beta TCR that is expressed by NK1.1+ thymocytes, NKT cells, and the majority of peripheral T cells. A small number of T cells may express an alternative heteromer of gamma/delta protein chains, known as the g/d TCR. These receptors participate in a complex with CD3, and with the co-receptors CD4 or CD8, to recognize and respond to antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death.
The H57-597 antibody is used as a phenotypic marker for T cells expressing the alpha-beta TCR. It is also widely used to cross-link surface TCR and thereby mimic TCR-mediated cell activation or induction of apoptosis. The antibody does not cross-react with cells expressing the g/d TCR.
Recent Publications:
Bescucci DM, Clarke ST, Brown CLJ, et al. The absence of murine cathelicidin-related antimicrobial peptide impacts host responses enhancing Salmonella enterica serovar Typhimurium infection. Gut Pathog. 2020 Nov 13;12(1):53. doi: 10.1186/s13099-020-00386-1. PMID: 33292444; PMCID: PMC7666523.
Karki R, Sharma BR, Lee E, et al. Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer.Ā JCI Insight. 2020;5(12):136720. Published 2020 Jun 18. doi:10.1172/jci.insight.136720.
Kondo M, Tanaka Y, Kuwabara T, Naito T, Kohwi-Shigematsu T and Watanabe A. 2015. J Immunol. doi: 10.4049/jimmunol.1501429. (Flow Cytometry)
| Name | APC-Cyanine7 Anti-Mouse TCR beta (H57-597) |
|---|---|
| Cat. No. | 25-5961 |
| Alternative Names | TCRb, TCRbeta, TCR-b chain, TCR-b, b-TCR |
| Gene ID | 21577 |
| Clone | H57-597 |
| Isotype | Armenian Hamster IgG |
| Reactivity | Mouse |
| Format | APC-Cyanine7 |
| Application | Flow Cytometry |
Description
The H57-597 antibody is specific for the beta chain of the mouse T cell Receptor (TCR). This cell surface protein combines with a second protein chain (alpha chain) to form the alpha-beta TCR that is expressed by NK1.1+ thymocytes, NKT cells, and the majority of peripheral T cells. A small number of T cells may express an alternative heteromer of gamma/delta protein chains, known as the g/d TCR. These receptors participate in a complex with CD3, and with the co-receptors CD4 or CD8, to recognize and respond to antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death.
The H57-597 antibody is used as a phenotypic marker for T cells expressing the alpha-beta TCR. It is also widely used to cross-link surface TCR and thereby mimic TCR-mediated cell activation or induction of apoptosis. The antibody does not cross-react with cells expressing the g/d TCR.
Recent Publications:
Bescucci DM, Clarke ST, Brown CLJ, et al. The absence of murine cathelicidin-related antimicrobial peptide impacts host responses enhancing Salmonella enterica serovar Typhimurium infection. Gut Pathog. 2020 Nov 13;12(1):53. doi: 10.1186/s13099-020-00386-1. PMID: 33292444; PMCID: PMC7666523.
Karki R, Sharma BR, Lee E, et al. Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer.Ā JCI Insight. 2020;5(12):136720. Published 2020 Jun 18. doi:10.1172/jci.insight.136720.
Kondo M, Tanaka Y, Kuwabara T, Naito T, Kohwi-Shigematsu T and Watanabe A. 2015. J Immunol. doi: 10.4049/jimmunol.1501429. (Flow Cytometry)
| Name | APC-Cyanine7 Anti-Mouse TCR beta (H57-597) |
|---|---|
| Cat. No. | 25-5961 |
| Alternative Names | TCRb, TCRbeta, TCR-b chain, TCR-b, b-TCR |
| Gene ID | 21577 |
| Clone | H57-597 |
| Isotype | Armenian Hamster IgG |
| Reactivity | Mouse |
| Format | APC-Cyanine7 |
| Application | Flow Cytometry |
